uppermost Get Printable Handwriting (up-per-most) 3 syllables Learn It! Spelling Test Definition adjective. at or nearest to the topadverb. 1 in or into the most prominent position as in the mind 2 in or into the highest position Example Sentence A masthead is the uppermost point of a mast. Synonyms topmost; utmost; at the top; highest Antonyms bottom; lowest Share with your friends: