lonesome Get Printable Handwriting (lone-some) 2 syllables Rhymes Learn It! Spelling Test Definition adjective. 1 being the only one; single and isolated from others; 2 marked by dejection from being by oneself Example Sentence Sally feels lonesome when her brothers are at school. Synonyms only; sole; solitary; single Antonyms multiple Rhymes Two Syllable Rhymes (1) lonesome Share with your friends: